The diamondback moth (Plutella xylostella) is global crop pest that causes millions of pounds worth of damage to crops worldwide. This is partly because it has developed field resistance to a wide variety of insecticides including Bt toxin. Using genetic linkage mapping and genomic approaches we have identified the genes for resistance to Bt toxin and spinosad. These discoveries will facilitate the management of resistance and future studies aimed at ameliorating resistance. Note that since Simon Baxter has left, we are no longer actively working in this area.
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Baxter, S. W. et al. Linkage mapping and comparative genomics using next-generation RAD sequencing of a non-model organism. PLoS ONE 6, e19315 (2011). Download
Baxter, S. W. et al. Parallel evolution of Bacillus thuringiensis toxin tesistance in Lepidoptera. Genetics 189, 675–679 (2011). Download
Baxter, S. W. et al. Mis-Spliced Transcripts of Nicotinic Acetylcholine Receptor α6 Are Associated with Field Evolved Spinosad Resistance in Plutella xylostella (L.). PLoS Genet 6, e1000802 (2010). Download